Raymond Dalgleish studied Cell Biology at the University of Glasgow, graduating in 1976. He undertook his PhD studies on the molecular genetics of globin genes at St. Mary’s Hospital Medical School, University of London with his degree being awarded in 1980. The next four years were spent as a Fogarty International Research Fellow in the Pulmonary Branch of the National Heart, Lung and Blood Institute at the National Institutes of Health, Bethesda, Maryland, USA cloning and analysing the first human collagen genes.
In 1984 he was appointed to a lectureship in the Department of Genetics, University of Leicester, UK, where he has remained since. His research initially focussed on the analysis of genes important in the determination of bone mineral density. In 1993 he began a database of human type I collagen mutations that lead to osteogenesis imperfecta (OI). The database was later expanded to include type III collagen mutations that lead to Ehlers-Danlos syndrome (EDS) type IV. The repertoire of genes has been greatly expanded and now comprises 16 genes for OI (https://oi.gene.le.ac.uk/) and 9 genes for EDS (https://eds.gene.le.ac.uk/). A key related activity was Raymond’s involvement in the development of the Locus Reference Genomic (LRG) (https://www.lrg-sequence.org) DNA reference sequence format as the basis for the reporting of mutations.
Raymond is a fromer chair of the HVP Gene/Disease Specific Database Advisory Council and is co-chair of the Database Panel of the Ehlers Danlos Syndrome Consortium.