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Thursday, February 19, 2015 - Saturday, February 21, 2015

Cambridge Healthtech Institute's Third Annual Genomics in MedicineData-Driven Personalized Diagnostics for Improved Outcomes

Event website


Dr. Robert C. Green to Deliver Keynote Address at Third Annual Genomics in Medicine in San Francisco

Update on the MedSeq and BabySeq Projects: Randomized Trials of Sequencing in Adults and Newborns
Robert C. Green, M.D., MPH, Director, G2P Research Program; Associate Director, Research, Partners Center for Personalized Genetic Medicine, Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School


Dr. Robert Green will present new data from the NIH-funded MedSeq and BabySeq Projects, two of the first randomized trials of genome sequencing versus standard of care, currently being conducted in adults and newborns, respectively. These projects explore the impact of integrating genome sequencing with the practice of medicine in both sick and healthy individuals, measuring medical, behavioral and economic outcomes for patients; and exploring the experience of non-geneticist physicians confronting genomic data in their patients.


Dr. Green is a physician-scientist in the Division of Genetics and Department of Medicine at Brigham and Women's Hospital and Harvard Medical School. His research interests have evolved from a focus on clinical trials and genetic epidemiology to a focus on translational genomics and health outcomes. He has been continuously funded by NIH for 21 years and has published over 300 articles. Key contributions have included the development of risk estimates based on family history and genetic markers, leadership and analysis of large multi-center treatment and prevention trials, including trials enriched through family history, and design, leadership and future planning of the first large-scale randomized clinical trials in translational genetics.
CONFERENCE-AT-A-GLANCEIMPACT AND UTILITY OF CLINICAL GENOMICS

Keynote Presentation: Update on the MedSeq and BabySeq Projects: Randomized Trials of Sequencing in Adults and Newborns
Robert C. Green, M.D., MPH, Director, G2P Research Program; Associate Director, Research, Partners Center for Personalized Genetic Medicine, Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School


The Vision and the Reality: One Cancer Center's Journey toward Genomic Medicine
Jeff Boyd, Ph.D., Senior Vice President, Molecular Medicine; The Robert C. Young., Chair in Cancer Research; Executive Director, Cancer Genome Institute; Chief, Division of Molecular Pathology; Professor, Cancer Biology Program, Fox Chase Cancer Center


The Impact of Genomic Variation in Clinical Development
Hakon Hakonarson, M.D., Ph.D., Director, Center for Applied Genomics, Children's Hospital of Philadelphia
INTEGRATION OF GENOMICS DATA

Integration of Genetics and Genomics into Medical Practice: Educational Challenges
Bruce R. Korf, M.D., Ph.D., Wayne H. and Sara Crews Finley Chair in Medical Genetics; Professor and Chair, Department of Genetics; Director, Heflin Center for Genomic Sciences, University of Alabama at Birmingham


Navigating the Genome: Realizing the True Promise of Genomic Medicine in the Clinic
James Evans, M.D., Ph.D., Bryson Distinguished Professor, Genetics and Medicine, Department of Genetics, University of North Carolina School of Medicine


Paradigm Cancer Diagnostic (PCDx): Development of a Clinical-Grade Next-Generation Sequencing Test for Cancer Patients
Robert Penny, M.D., Ph.D., CEO, Paradigm
Sponsored by Paradigm


Luncheon Presentation: Enabling Translational Diagnostics through Discovery and Development of Signatures with Unified DNA and RNA NGS Panels
Brian Haynes, Ph.D., Senior Scientist, Asuragen
Sponsored by Asuragen
PRACTICAL CONSIDERATIONS FOR INTEGRATION OF GENOMICS DATA INTO MEDICAL PRACTICE

PANEL DISCUSSION: Practical Considerations for Integration of Genomic Data in Medical Practice
Moderator: James Evans, M.D., Ph.D., Bryson Distinguished Professor, Genetics and Medicine,Genetics, University of North Carolina School of Medicine
IDENTIFICATION AND ANNOTATION OF VARIANTS

Genomic Approaches to Causal Variant Identification
Gregory Cooper, Ph.D., Faculty Investigator, HudsonAlpha Institute for Biotechnology


Decoding the Patient's Genome: Clinical Use of Genome-Wide Sequencing Data
Elizabeth Worthey, Ph.D., Assistant Professor, Pediatrics & Bioinformatics Program, Human & Molecular Genetics Center, Medical College of Wisconsin


Clinical Grade Annotations: Public Data Resources for Interpreting Genomic Variants
Gabe Rudy, Vice President, Product Development, Golden Helix
INTERPRETATION OF VARIANTS

Rapid Genome Sequencing, Interpretation and Management in the Neonatal Intensive Care Unit
Euan Ashley, D.Phil., Associate Professor, Medicine and Genetics; Director, Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine


Reinterpreting Results from Large-Scale Clinical Sequencing or Genetic Testing
Peter Byers, M.D., Director, Center for Precision Diagnostics; Professor, Pathology, Medicine & Genome Sciences, University of Washington School of Medicine


The Clinical Ramifications of Divergent Oncogenic Pathways in Tumor Evolution
Hanlee Ji, M.D., Assistant Professor, Division of Oncology, Department of Medicine, Stanford University School of Medicine; Senior Associate Director, Stanford Genome Technology Center


Sponsored Presentation (Opportunities Available)
SHARING AND MINING PATIENT DATA

Impact & Utilization of Integrating Genomics Data into EMRs
Dan Roden, M.D., William Stokes Professor, Experimental Therapeutics; Professor, Medicine and Pharmacology; Assistant Vice Chancellor, Personalized Medicine, Vanderbilt University


Mining Clinical Genomics Data
Joel Dudley, Ph.D., Director, Biomedical Informatics; Assistant Professor of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai


The ClinGen Resource: Sharing Data. Building Knowledge. Improving Care.
Christa Lese Martin, Ph.D., FACMG, Director & Senior Investigator, Autism & Developmental Medicine Institute (ADMI), Geisinger Health System