The Micronutrient Genomics Project (MGP) Workshop
10th May
The Micronutrient Genomics Project (MGP) is a community driven project facilitating the development of systematic capture, storage, management, analyses, and dissemination of data and knowledge generated by biological studies focused on micronutrient – genome interactions. MGP’s workshop is the third in a series which aims to demonstrate the potential, elucidate the strategy, establish the necessary multidisciplinary links, build the organizational structures and develop the knowledge base. This MGP workshop is being held at UNESCO to foster collaborations with the Human Variome Project (HVP). The HVP and MGP share a common interest in analyzing, characterizing, and databasing genetic variation in the world’s populations. The MGP is focusing on micronutrients since they influence multiple metabolic pathways and optimum micronutrient supply is important for maintenance of homeostasis in metabolism and maintaining health throughout the lifecourse.
Existing research collects fragments of information, which are not stored systematically and not optimally disseminated. The Micronutrient Genomics Project (MGP) is a community driven project facilitating the development of systematic capture, storage, management, analyses, and dissemination of data and knowledge generated by biological studies focused on micronutrient – genome interactions. The MGP creates a public portal and open source bioinformatics toolbox for all "omics" information and evaluation of micronutrient and health studies. The core of the project focuses on access to, and visualization of, genetic/genomic, transcriptomic, proteomic and metabolomic information related to micronutrients. A series of additional features (modelling, flux analysis, pathway, and links between them) can be added as the portal develops.
For each micronutrient, an expert group will be established combining the various relevant disciplines. Each expert group will (i) collect all available knowledge, including genetic variation, (ii) collaborate with bioinformatics teams towards constructing the pathways and biological networks, and (iii) publish their findings on a regular basis. The project is transparently coordinated, regular meetings are organized and dissemination is arranged through a toolbox web portal, a communications website and dedicated publications. This Workshop will illustrate the purpose and usefulness of the MGP database and invite groups working on micronutrients to participate in these activities.
This MGP Workshop is sponsored by NuGO and the Division of Personalized Nutrition and Medicine of the US FDA/National Center for Toxicological Research.
MGP Coordinating Group
| Ahmed El-Sohemy PhD | a.el.sohemy@utoronto.ca | University of Toronto (Canada) |
| Michael Fenech PhD | Michael.Fenech@csiro.au | CSIRO, Adelaide (Australia) |
| John Hesketh PhD (Chair) | j.e.hesketh@ncl.ac.uk | University of Newcastle (England) |
| Jim Kaput PhD | james.kaput@fda.hhs.gov | FDA/NCTR (United States) |
| Harry McArdle PhD | h.mcardle@abdn.ac.uk | University of Aberdeen (UK) |
Draft Schedule
| 8.30 - 9.15 a.m. | Registration | 7 place de Fontenoy entrance, before security - no pre registration means no badge = no entry! |
| 9:15 - 9.45 a.m. | Introduction to Micronutrient Genomics Project: Selenium as an exemplar | John Hesketh (NuGO; Newcastle Upon Tyne) |
| 9:45 – 10.05 a.m. | EURRECA: Overview and objectives | Sue Fairweather-Tait (Norwich) |
| 10.05 - 10:25 a.m. | Micronutrients, GWAS, and Candidate Genes | Ahmed El-Sohemy (Toronto) Jim Camakaris (Melbourne) |
| 10.25 - 10:35 a.m. | Micronutrient Genomics & Human Variome Workshops. International Conference on Nutrigenomics - September 2010. Brazil |
Lucia Regina Ribeiro (Sao Paolo) |
| 10:35 – 11.00 a.m. | Coffee Break | |
| 11.00 - 11.20 a.m. | Genetic Regulation of Metal Homeostasis with Emphasis on the Copper Paradigm | Jim Camakaris (Melbourne) |
| 11.20 – 11:40 a.m. | Metabolic Effects of Variants of Micronutrient Genes: the -carotene 15,15’ Monooxygenase Example | Georg Leitz (Newcastle) |
| 11:40 - 12:00 p.m. | Micronutrient Requirements for World Populations: Challenges and Opportunities | Barbara Burlingame (Rome) |
| 12.00 - 12.20 p.m. | NextGen Sequencing of Exons of Micronutrient Genes | Baitang Ning (Jefferson) |
| 12:20 – 1:30 p.m. | Lunch | |
| 1:30 – 2:00 p.m. | MGP Bioinformatics: Linking Pathways to Gene Variants | Chris Evelo (Maastricht) |
| 2:00 – 4:30 p.m. | Discussion Topics
Common tools and needs of HVP and MGP (e.g., tools, databases, work on specific genes or gene categories, lessons learned) How to translate a specific genetic variation into a phenotype influenced by nutrition / micronutrients Browsing and visualisation of genetic variations in the context of biological networks Building International Collaborations among HVP and MGP
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Coordinators - Ben van Ommen, John Hesketh, Jim Kaput |
* Common tools and needs of HVP and MGP (tools, databases, work on specific genes or gene categories, lessons learned, (etc)
* How to translate a specific genetic variation into a phenotype which includes accounting for nutrition / micronutrients
* Browsing and visualization of genetic variations (if possible in the context of biological networks).
* Building International Collaborations among HVP and MGP
Registration
Registrations are invited through the application process on the HVP website. Note, places are limited in the UNESCO building. This meeting has been generously sponsored by NuGO so there will be no registration fee however you MUST register at the time of registering for the HVP meeting as numbers are limited due to space constraints. If you are not attending the HVP meeting you can still attend but you will need to REGISTER WITH THE SECRETARIAT AS THE ONLINE SYSTEM DOES NOT ALLOW IT WITHOUT HVP REGISTRATION. Please fill out the Special Satellite Registration Form linked here ONLY IF YOU ARE NOT ATTENDING THE HVP IN WHICH CASE YOU CAN BOOK THIS ONLINE